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Bone Tissue |
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A quantitative study of porosity classes in trabecular bone by MR-Relaxation and MR-Cryoporometry
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Lo studio del tessuto osseo e dell’osteoporosi mediante NMR
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A quantitative study of porosity classes in trabecular bone by MR-Relaxation and MR-Cryoporometry
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The interest in Magnetic Resonance studies of bone is increasing as new
noninvasive MR Imaging methods are being developed to study bone
microstructure and the effects of diseases such as osteoporosis.
In a preliminary study,
the feasibility and potential for the combined use of MR-Relaxation
(MRR) of
1H
nuclei and MR-Cryoporometry (MRC) for
the study of bone microstructure
was demonstrated.
The study has been extended to the quantitative characterization of
particular classes of pore spaces in trabecular bone, with a special
emphasis on the intratrabecular space where MRC is expected to be more
sensitive. It has been shown that
from MRR it is possible to distinguish
between
the signal of water in the large inter-trabecular spaces
and
that in the smaller intra-trabecular spaces.
This work provides solid validation of those results with the
characterization of different structures in the bone pores for a large
set of samples. MRC offers
evidence for the existence of pores with diameters less than 4000Å in
bone. MRR analysis allows one to
distinguish and quantify the fraction of pore volume in the inter- and
intra-trabecular spaces in such a way that the bone volume fraction
(BVF) can be determined. BVF is
defined as the ratio of solid bone volume (including any
intra-trabecular pore space) to total bone volume (including all pore
space); it is a parameter usually determined by histomorphometric
analysis, quantitative 3D X-Ray or MRI microtomography.
In addition, our combined magnetic resonance methods allow one to
measure the internal porosity of the trabeculae (Φtrab),
defined as the ratio of intra-trabecular pore volume to the total volume
occupied by the trabeculae.
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click on the image to download the poster (660KB) |
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click on the image to download the poster (1.3Mb) |
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