Bone Tissue

 

A quantitative study of porosity classes in trabecular bone by MR-Relaxation and MR-Cryoporometry

 

Lo studio del tessuto osseo e dell’osteoporosi mediante NMR

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

A quantitative study of porosity classes in trabecular bone by MR-Relaxation and MR-Cryoporometry

 

The interest in Magnetic Resonance studies of bone is increasing as new noninvasive MR Imaging methods are being developed to study bone microstructure and the effects of diseases such as osteoporosis.  In a preliminary study, the feasibility and potential for the combined use of MR-Relaxation (MRR) of 1H nuclei and MR-Cryoporometry (MRC) for the study of bone microstructure was demonstrated. The study has been extended to the quantitative characterization of particular classes of pore spaces in trabecular bone, with a special emphasis on the intratrabecular space where MRC is expected to be more sensitive.  It has been shown that from MRR it is possible to distinguish between the signal of water in the large inter-trabecular spaces and that in the smaller intra-trabecular spaces.  This work provides solid validation of those results with the characterization of different structures in the bone pores for a large set of samples.  MRC offers evidence for the existence of pores with diameters less than 4000Ĺ in bone. MRR analysis allows one to distinguish and quantify the fraction of pore volume in the inter- and intra-trabecular spaces in such a way that the bone volume fraction (BVF) can be determined.  BVF is defined as the ratio of solid bone volume (including any intra-trabecular pore space) to total bone volume (including all pore space); it is a parameter usually determined by histomorphometric analysis, quantitative 3D X-Ray or MRI microtomography.  In addition, our combined magnetic resonance methods allow one to measure the internal porosity of the trabeculae (Φtrab), defined as the ratio of intra-trabecular pore volume to the total volume occupied by the trabeculae.
 

 

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Lo studio del tessuto osseo e dell’osteoporosi mediante NMR

 

click on the image to download the poster (1.3Mb)